The Premier League is back with Matchday 16 of the 2025-26 season.
And we are back with another round of betting tips, focused on some of the biggest matches this weekend.
So, check them out below, and all the latest Premier League odds on NetBet are available to view, as well as great promotions like our Weekly Football Acca Offer!
*All odds are subject to change
Liverpool vs Brighton: Player to score or assist – Alexander Isak @ 1.70
Saturday’s game at Anfield feels like a big one for Isak after yet another poor showing at Inter Milan on Tuesday. The Swede is yet to score a home Premier League goal in 2025-26, which is not ideal when you cost £125 million! But players of Isak’s quality usually deliver when the criticism is loudest, so backing him to land a decisive blow against Brighton feels a sensible course of action. Isak scored twice in three appearances vs the Seagulls last season, and may thrive with the additional responsibility of filling the void left by the exiled Mo Salah.
Arsenal vs Wolves: Anytime goalscorer – Bukayo Saka @ 2.12
Saka was given a welcome rest in Arsenal’s 3-0 win at Club Brugge, only appearing off the bench in the latter stages of the game. That is pretty ominous for winless Wolves, who have conceded 33 goals in just 15 Premier League games this season. The Gunners are formidable at home too with six wins from seven and a goal difference of +16, while Saka loves playing at the Emirates. Three of his four top-flight strikes in 2025-26 have come in front of the Arsenal faithful, and the England international has also scored in three of his previous four matches vs Wolves. Given Saka could also be on penalty duty, the odds here look very favourable indeed.
Sunderland vs Newcastle: Bruno Guimaraes to commit over 2.5 fouls @ 2.00
The first Tyne-Wear derby in the Premier League for close to 10 years promises fireworks – and fouls! The referee at the Stadium of Light on Sunday could be very busy, and Guimaraes is always a contender for top spot in the foul count standings. He always get sucked into the heat of battle, especially in fixtures with an extra bit of needle. Guimaraes, who has been in fine scoring form of late, has committed 24 fouls this season, the fifth-highest total in the division. Up against another fiery character in Granit Xhaka, we expect the Brazilian’s tally to be closer to the 30 mark when the full-time whistle is blown.
Brentford to beat Leeds @ 1.95
After two tricky away games vs Arsenal and Tottenham, Brentford return to the Gtech Stadium – where they have been formidable this season. With five wins from seven, the Bees are the fourth-best home team in the division ahead of Matchday 16. And the less said about Leeds’ away form, the better. Yes, Daniel Farke’s side enter this fixture on the back of great home performances vs Chelsea (3-1) and Liverpool (3-3), but away from Elland Road the Whites have lost six of seven. Only Wolves have a worse away record in the Premier League this season, which says it all really. Over to you, Brentford!
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